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平喘治疗可改善阿尔茨海默氏病患者的认知功能|阿尔茨海默氏症是什么

时间:2019-01-21 来源:东星资源网 本文已影响 手机版

  【摘要】目的 根据全球哮喘防治倡议(2008版)方案(GINA)对哮喘进行治疗,观察平喘治疗对阿尔茨海默氏病(Alzheimer"s disease,AD)患者的认知功能和功能状态的影响。方法 筛选轻度或中度AD患者随机分成两组,均给予抗哮喘治疗及抗AD治疗。利用画钟试验和简易智力状态检查量表(MMSE)在研究开始、6个月后及1年后等3个时间点对患者认知功能进行评估,并评估患者的功能状态及哮喘控制效果。结果 平喘治疗6个月后实验组难控型哮喘患者比例降低,而易控型哮喘患者的人数显著增加(P   总之,充分平喘治疗可改善轻度或中度AD患者的认知功能及工具性日常生活活动能力。然而,平喘治疗对重度AD患者的有效性仍需要进一步的临床观察。
  参考文献
  [1] Khachaturian ZS. Perspective on the Alzheimer"s disease neuroimaging initiative: progress report and future plans [J]. Alzheimers Dement, 2010, 6(3):199-201.
  [2] King JT Jr, Tsevat J, Roberts MS. Cognitive impairment and preferences for current health [J]. Health Qual Life Outcomes, 2009, 7:1.
  [3] Antonelli-Incalzi R, Corsonello A, Trojano L, et al. Screening of cognitive impairment in chronic obstructive pulmonary disease [J]. Dement Geriatr Cogn Disord, 2007, 23(4):264-270.
  [4] Bateman ED, Hurd SS, Barnes PJ, et al. Global strategy for asthma management and prevention: GINA executive summary [J]. Eur Respir J, 2008, 31(1):143-178.
  [5] Ohrui T, Arai H, Ichinose M, et al. Relationship between asthma severity and progression of Alzheimer"s disease [J]. Thorax, 2002, 57(6):561.
  [6] Shawn Christopher Shea. Chapter 13 - Contemporary Clinical Interviewing: Integration of the DSM-IV, Managed Care Concerns, Mental Status, and Research [J]. Handbook of Psychological Assessment (Third Edition), 1999, 339-368.
  [7] McKhann G, Drachman D, Folstein M, et al. Clinical diagnosis of Alzheimer"s disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer"s Disease [J]. Neurology, 1984, 34(7):939-944.
  [8] Folstein MF, Folstein SE, McHugh PR. "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician [J]. J Psychiatr Res, 1975, 12(3):189-198.
  [9] Peters R, Pinto EM. Predictive value of the Clock Drawing Test. A review of the literature [J]. Dement Geriatr Cogn Disord, 2008, 26(4):351-355.
  [10] Katz S, Ford AB, Moskowitz RS, et al. Studies of illness in the aged. The index of ADL: A standardized measure of biological psychosocial function [J]. JAMA, 1963, 185:914-919.
  [11] Albert SM, Bear-Lehman J, Burkhardt A, et al. Variation in sources of clinician-rated and self-rated instrumental activities of daily living disability [J]. J Gerontol A Biol Sci Med Sci, 2006, 61(8):826-831.
  [12] Thomas M, Kay S, Pike J, et al. The Asthma Control Test (ACT) as a predictor of GINA guideline-defined asthma control: analysis of a multinational cross-sectional survey [J]. Prim Care Respir J, 2009, 18(1):41-49.
  [13] Bozek A, Jarzab J. Adherence to asthma therapy in elderly patients [J]. J Asthma, 2010, 47(2):162-165.
  [14] Mancuso CA, Wenderoth S, Westermann H, et al. Patient-reported and physician-reported depressive conditions in relation to asthma severity and control [J]. Chest, 2008, 133(5):1142-1148.
  [15] Hillen T, Davies S, Rudd AG, et al. Self ratings of health predict functional outcome and recurrence free survival after stroke [J]. J Epidemiol Community Health, 2003, 57(12):960-966.
  [16] Brown ES, Denniston D, Gabrielson B, et al. Randomized, double-blind, placebo-controlled trial of acetaminophen for preventing mood and memory effects of prednisone bursts [J]. Allergy Asthma Proc, 2010, 31(4):331-336.

标签:平喘 阿尔 病患者 认知